Expertise / Equipment / Partners

APPLIED

SUPERCRITICAL

FLUIDS

EXPERTISE / EQUIPMENT / PARTNERS

APPLIED SUPERCRITICAL FLUIDS (ASF):
Supercritical Fluids Technology
and its Applications

Supercritical Fluids Technology & Expertise:

  • Design of SCF Equipment
  • Supercritical Fluids Processes Engineering
  • Implementation of the Technology on Client’s Site
  • Customers Training in Supercritical Fluids Technology
  • Definition and Validation of Users Requirements, Processes & Functional Specifications
  • Definition of Sales Agreements between Clients and ASF Partners
  • Public and Governmental Markets
  • Quality Plan, Current Good Manufacturing Practice (cGMP): Quality/Manufacturing Standards Guidance’s applied to Pharmaceutical or Biomedical
  • Standardization Procedures
  • Client’s Follow-Up / Consulting / Processes & Technical Questions

Activities:

Supercritical Fluids Applications / Process Engineering:

  • Supercritical Fluid Extractions (SFE)
  • Supercritical Fluid Fractionation (SFF)
  • Hydrothermal Treatments; Example: Supercritical Water Oxidation (SCWO), Subcritical Water Extraction, …
  • Supercritical Fluid Drying (SFD); Example: Aerogels Drying
  • Atomization and Particles or Powder Formation (SFP): Encapsulation, Impregnation, …
  • Cannabinoids or other Active Ingredients Extraction (Example: CBD) contained within Cannabis plant, following a process using pressurized and heated CO2, at production scale and with therapeutic & medicinal purposes
  • Textile Dyeing Process
  • Cleaning and Purification Processes
  • Others, …

Equipment:

  • SCF Equipment Design / Engineering
  • « High-Pressure / High-Temperature » Reactors / Autoclaves
  • Implementation of SCF Equipment from Lab to Pilot and Production Scales on client’s site, following specific partnerships between clients and partners
  • « Scale Up » feasibility studies: from R&D and Lab Scale to Pilot and Industrial Scales

SCF Equipment Realization: ASF PARTNERS

Supercritical Fluids R&D Skid for Extraction, Drying, Atomization & Impregnation

  • Extraction, Drying & Supercritical AntiSolvent (SAS®) Processes

  • 100ml and 200ml Autoclaves separated in two skids = numbers of combinations

  • 1000 bar & 150°C @ 6L/h with CO2

  • Automated Pressure Control

  • EUROTHERM™ Controllers & Recorder (Nanodac™) = data logging & user-friendly interface

  • Easy hand-tighten top lids

  • Filtering baskets & Spraying Nozzle = compounds micronization/atomization/extraction/drying

  • Sapphire windows = real time process visualization & UV analysis

  • Dual Pistons CO2 Pump & HPLC Co-solvent Pump

    = modify main solvent’s polarity in Extraction’s mode

    = achieve SAS® process

  • Whole Instrumentation included

 2 Liters SCF Pilot for Supercritical CO2 Extraction and Subcritical Water Extraction
  • Both Supercritical CO2 & Subcritical Water Extraction
  • 350 bars & +230°C @ 20 Kg/h
  • Two Co-solvent Pumps = Polarity’s Adjustment & Liquid Solvent Injection
  • Optimized Filtering Basket
  • Magnetic Coupling Mixer = activate Reactions 
  • Two well-designed High-Pressure Cyclonic Separators = CO2 Recycling
  • Cold Trap / Adsorbent Bed Filter = capture most volatile particles (Aromas)
  • SIEMENS™ PLC & user-friendly Touch Screen Panel HMI = P&ID and Controls on Screen
  • Automated Liquid CO2 Storage & Extracts Collection

Supercritical CO2 Purification Skid for Biomedical Application
  • Supercritical CO2 Purification Process
  • 250 bars & +5/+130°C 
  • Clean-In-Place (CIP)
  • Sterilization
  • GMP Rated (Biomedical Requirements)
  • SIEMENS™ PLC & user-friendly Touch Screen Panel HMI = P&ID and Controls on Screen

Supercritical CO2 Extraction Production Unit
  • Supercritical CO2 Extraction @ Production Scale
  • 350 bars & +100°C @ 3 tons/hour 
  • 2x500L Effective Capacity
  • X2 HP Separators & x1 Collector
  • Fully Automated
  • ATEX Rated

SITEMAP

CONTACT: polanz.romain@appliedsupercriticalfluids.com
18, Rue Henner 54000 Nancy – FRANCE
+33 (0)6.20.48.71.76. / +33 (0)3.54.12.12.78